Prognostic significance of complement alleles Bf and C4 in early rheumatoid arthritis
Identifieur interne : 002A25 ( Main/Exploration ); précédent : 002A24; suivant : 002A26Prognostic significance of complement alleles Bf and C4 in early rheumatoid arthritis
Auteurs : L. Paimela [Finlande] ; M. Leirisalo-Repo [Finlande] ; M-L. Lokki [Finlande] ; S. Koskimies [Finlande]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 1996-11-01.
English descriptors
- KwdEn :
- Teeft :
- Allele, Antirheumatic treatment, Arthritis, Arthritis rheum, Bfss phenotype, Complement alleles, Disease activity, Drug toxicity, Higher disease activity, Intramuscular gold, Major histocompatibility, Null allele, Null alleles, Present study, Prognostic, Prognostic significance, Rheum, Rheumatoid, Rheumatoid arthritis, Side effects, Subgroup, Sulphasalazine treatment, Toxicity.
Abstract
Summary: The prognostic significance of class III major histocompatibility complex complement components, factor B (Bf), C4A and C4B, were studied in a 3-year prospective study of 73 patients with early RA. Patients with C4B null allele had higher disease activity with more radiological progression than patients with C4A null allele or patients without null alleles. C4B null allele also associated with increased susceptibility to side effects from antirheumatic treatment. The Bf phenotypes did not associate with the severity of RA. C4B null allele may have prognostic significance in determining a special subgroup of RA patients with a more complicated course of the disease.
Url:
DOI: 10.1007/BF02238550
Affiliations:
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Koskimies</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DE1629C3C58BBB598D0CAD66110EA1631095BA37</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1007/BF02238550</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-LSF73H9D-3/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001E68</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E68</idno><idno type="wicri:Area/Istex/Curation">001E68</idno><idno type="wicri:Area/Istex/Checkpoint">001815</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001815</idno><idno type="wicri:doubleKey">0770-3198:1996:Paimela L:prognostic:significance:of</idno><idno type="wicri:Area/Main/Merge">002A77</idno><idno type="wicri:Area/Main/Curation">002A25</idno><idno type="wicri:Area/Main/Exploration">002A25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Prognostic significance of complement alleles Bf and C4 in early rheumatoid arthritis</title><author><name sortKey="Paimela, L" sort="Paimela, L" uniqKey="Paimela L" first="L." last="Paimela">L. Paimela</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Rheumatology, Helsinki City Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Leirisalo Repo, M" sort="Leirisalo Repo, M" uniqKey="Leirisalo Repo M" first="M." last="Leirisalo-Repo">M. Leirisalo-Repo</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lokki, M L" sort="Lokki, M L" uniqKey="Lokki M" first="M-L." last="Lokki">M-L. Lokki</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Red Cross Blood Transfusion Service, Tissue Typing Laboratory, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Koskimies, S" sort="Koskimies, S" uniqKey="Koskimies S" first="S." last="Koskimies">S. Koskimies</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Red Cross Blood Transfusion Service, Tissue Typing Laboratory, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Rheumatology</title><title level="j" type="abbrev">Clin Rheumatol</title><idno type="ISSN">0770-3198</idno><idno type="eISSN">1434-9949</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>London</pubPlace><date type="published" when="1996-11-01">1996-11-01</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="594">594</biblScope><biblScope unit="page" to="598">598</biblScope></imprint><idno type="ISSN">0770-3198</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0770-3198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complement Alleles</term><term>Prognosis</term><term>Rheumatoid Arthritis</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Antirheumatic treatment</term><term>Arthritis</term><term>Arthritis rheum</term><term>Bfss phenotype</term><term>Complement alleles</term><term>Disease activity</term><term>Drug toxicity</term><term>Higher disease activity</term><term>Intramuscular gold</term><term>Major histocompatibility</term><term>Null allele</term><term>Null alleles</term><term>Present study</term><term>Prognostic</term><term>Prognostic significance</term><term>Rheum</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Side effects</term><term>Subgroup</term><term>Sulphasalazine treatment</term><term>Toxicity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The prognostic significance of class III major histocompatibility complex complement components, factor B (Bf), C4A and C4B, were studied in a 3-year prospective study of 73 patients with early RA. Patients with C4B null allele had higher disease activity with more radiological progression than patients with C4A null allele or patients without null alleles. C4B null allele also associated with increased susceptibility to side effects from antirheumatic treatment. The Bf phenotypes did not associate with the severity of RA. C4B null allele may have prognostic significance in determining a special subgroup of RA patients with a more complicated course of the disease.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Paimela, L" sort="Paimela, L" uniqKey="Paimela L" first="L." last="Paimela">L. Paimela</name></noRegion><name sortKey="Koskimies, S" sort="Koskimies, S" uniqKey="Koskimies S" first="S." last="Koskimies">S. Koskimies</name><name sortKey="Leirisalo Repo, M" sort="Leirisalo Repo, M" uniqKey="Leirisalo Repo M" first="M." last="Leirisalo-Repo">M. Leirisalo-Repo</name><name sortKey="Lokki, M L" sort="Lokki, M L" uniqKey="Lokki M" first="M-L." last="Lokki">M-L. Lokki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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